Whereas small-count MBL rarely progresses to CLL, higher-count MBL progresses to CLL demanding therapy in a level of 1% to 2% a year. High-rely MBL is distinguished from Rai 0 CLL determined by whether or not the B-mobile depend is previously mentioned or beneath 5 × 109/L. Although men and women with the two high-rely MBL and CLL Rai phase 0 are